2250440-41-4

2250440-41-4 structure

Name: Vilobelimab
Chemical Name: Vilobelimab
CAS Number: 2250440-41-4
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2023-03-15 16:57:03
Modify Date: 2024-04-06 09:41:08
Vilobelimab (CaCP-29, IFX-1) is a monoclonal anti-C5a antibody to the allergen C5a, a pro-inflammatory complement division product that plays a central role in mediating organ dysfunction. Vilobelimab acts as a C5a inhibitor, inhibiting neutrophil activation, chemotaxis, and reducing inflammatory signalling, and may be used in studies related to sepsis, COVID-19, etc[1].

Name	Vilobelimab

Description	Vilobelimab (CaCP-29, IFX-1) is a monoclonal anti-C5a antibody to the allergen C5a, a pro-inflammatory complement division product that plays a central role in mediating organ dysfunction. Vilobelimab acts as a C5a inhibitor, inhibiting neutrophil activation, chemotaxis, and reducing inflammatory signalling, and may be used in studies related to sepsis, COVID-19, etc[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV Signaling Pathways >> Immunology/Inflammation >> Complement System Research Areas >> Inflammation/Immunology
In Vitro	Vilobelimab selectively neutralises C5a in a dose-dependent manner without blocking the formation of the membrane attack complex and without leading to detectable safety concerns In certain clinical studies of patients suffering from severe sepsis and septic shock[1].
References	[1]. Michael Bauer, et al. Efficacy and Safety of Vilobelimab (IFX-1), a Novel Monoclonal Anti-C5a Antibody, in Patients With Early Severe Sepsis or Septic Shock-A Randomized, Placebo-Controlled, Double-Blind, Multicenter, Phase IIa Trial (SCIENS Study). Crit Care Explor. 2021 Nov 17;3(11):e0577.

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