2225850-33-7

2225850-33-7 structure
2225850-33-7 structure
  • Name: Zelminemab
  • Chemical Name: Zelminemab
  • CAS Number: 2225850-33-7
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Signaling Pathways GPCR/G Protein Adenylate Cyclase
  • Create Date: 2023-01-08 09:45:22
  • Modify Date: 2024-01-10 20:09:36
  • Zelminemab (AMG-301) is a human monoclonal antibody that inhibits PACAP type I (PAC1) receptor[1].

Name Zelminemab
Description Zelminemab (AMG-301) is a human monoclonal antibody that inhibits PACAP type I (PAC1) receptor[1].
Related Catalog
In Vivo Zelminemab(10 mg/kg;i.v.;一次)降低 TCC 中的伤害性神经元活动[2]。 Animal Model: Sprague-Dawley rats, electricalstimulation was performed on the intact dura mater abovethe middle meningeal artery[2]. Dosage: 10 mg/kg Administration: i.v.; once Result: Induced an inhibition of stimulus-evoked nociceptive activity in the trigeminocervical com-plex (TCC).
References

[1]. Eloisa Rubio-Beltrán, et al. PACAP38 and PAC1 receptor blockade: a new target for headache? J Headache Pain. 2018 Aug 7;19(1):64.  

[2]. Hoffmann J, et al. PAC-1 receptor antibody modulates nociceptive trigeminal activity in rat. Cephalalgia. 2016;36(1S):141–141.

No Any Chemical & Physical Properties