2155851-88-8

2155851-88-8 structure

2155851-88-8 structure

Name: Axatilimab
Chemical Name: Axatilimab
CAS Number: 2155851-88-8
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK c-Fms
Create Date: 2023-02-05 00:46:42
Modify Date: 2024-04-09 19:17:23
Axatilimab (SNDX-6352) is a humanized IgG4 antibody with high affinity to CSF-1R. Axatilimab can be used for the research of chronic graft versus host disease (cGVHD) and neoplastic diseases[1][2].

Name	Axatilimab

Description	Axatilimab (SNDX-6352) is a humanized IgG4 antibody with high affinity to CSF-1R. Axatilimab can be used for the research of chronic graft versus host disease (cGVHD) and neoplastic diseases[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms
In Vitro	Axatilimab (SNDX-6352) 通过与 CSF-1R 结合并阻断其两种已知配体 CSF-1 和 IL-34 的激活来影响单核细胞和巨噬细胞的迁移、增殖、分化和存活。
References	[1]. Arora M, et al. Phase 1 study of axatilimab (SNDX-6352), a CSF-1R humanized antibody, for chronic graft-versus-host disease after 2 or more lines of systemic treatment. Blood, 2020, 136: 1-2. [2]. Tiessen R, et al. First in human, single ascending dose study in healthy volunteers of SNDX-6352, a humanized IgG4 monoclonal antibody targeting colony stimulating factor-1 receptor (CSF-1R). J Immunother Cancer, 2016, 5: P505.

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