1918149-01-5

1918149-01-5 structure

1918149-01-5 structure

Name: Bintrafusp alfa
Chemical Name: Bintrafusp alfa
CAS Number: 1918149-01-5
Molecular Formula:
Molecular Weight:
Catalog: Research Areas Cancer
Create Date: 2023-05-19 13:27:16
Modify Date: 2024-04-08 17:13:42
Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer[1].

Name	Bintrafusp alfa

Description	Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer
In Vitro	Bintrafusp alfa 可以赋予长期保护性免疫，降低调节性 T 细胞功能，显着增加 CD8+ T 细胞和自然杀伤细胞浸润，并减少肿瘤内骨髓来源的抑制细胞浸润[1]。
References	[1]. Strauss J, et, al. Bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in patients with human papillomavirus-associated malignancies. J Immunother Cancer. 2020 Dec;8(2):e001395.

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