2093956-19-3

2093956-19-3 structure

2093956-19-3 structure

Name: Prolgolimab
Chemical Name: Prolgolimab
CAS Number: 2093956-19-3
Molecular Formula:
Molecular Weight:
Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
Create Date: 2023-04-01 09:45:18
Modify Date: 2024-04-11 15:46:31
Prolgolimab (BCD-100) is a human IgG1 anti-PD-1 monoclonal antibody containing the Fc-silencing 'LALA' mutation. Prolgolimab can be used for the research of advanced melanoma[1].

Name	Prolgolimab

Description	Prolgolimab (BCD-100) is a human IgG1 anti-PD-1 monoclonal antibody containing the Fc-silencing 'LALA' mutation. Prolgolimab can be used for the research of advanced melanoma[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Immunology/Inflammation >> PD-1/PD-L1
Target	PD-1[1]
In Vitro	Prolgolimab is an IgG1 anti-PD-1 mAb that contains the Fc-silencing LALA mutation, which provides an immunopotentiating advantage by abolishing the interaction between the Fcregion of the antibody and FcgR expressed on various immune cells, thus blocking the possible effector functions of the antibody[1].
References	[1]. Tjulandin S, et, al. Novel PD-1 inhibitor prolgolimab: expanding non-resectable/metastatic melanoma therapy choice. Eur J Cancer. 2021 May;149:222-232.

No Any Chemical & Physical Properties