Name | Ociperlimab |
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Description | Ociperlimab is a humanized IgG1 anti-TIGIT antibody. Ociperlimab binds to the extracellular domain of human TIGIT with high affinity (KD = 0.135 nM). Ociperlimab blocks the interaction between TIGIT and its ligands PVR or PVR-L2. Ociperlimab can be used in research of cancer[1][2]. |
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Related Catalog | |
In Vitro | Ociperlimab (BGB-A1217; 0-10 μg/mL) 增强增强巨细胞病毒特异性 T 细胞分泌的 IFN-γ[1]。 Ociperlimab (1-1000 ng/mL) 以 Fc 依赖性方式激活自然杀伤细胞和单核细胞[1]。 Ociperlimab 在体外通过 Fc 依赖性内吞作用从 T 细胞表面去除 TIGIT[1]。 |
In Vivo | Ociperlimab (BGB-A1217; 3 和 10 mg/kg; 腹腔注射; CT26 WT 荷瘤人源化 TIGIT 敲入小鼠和 MC38 荷瘤人源化 TIGIT 敲入小鼠) 以 Fc 依赖性方式产生抗肿瘤功效[1]。 Animal Model: CT26 WT tumor-bearing humanized TIGIT knock-in mice and MC38 tumor-bearing humanized TIGIT knock-in mice[1] Dosage: 3 and 10 mg/kg Administration: Intraperitoneal injection Result: Inhibited tumor growth compared to the single agent treatment groups. |
References |
No Any Chemical & Physical Properties |