2417988-00-0

2417988-00-0 structure

Name: JB062
Chemical Name: JB062
CAS Number: 2417988-00-0
Molecular Formula: C₁₉H₁₇NO₄
Molecular Weight: 323.34
Catalog: Signaling Pathways Cytoskeleton Myosin
Create Date: 2023-04-05 10:25:09
Modify Date: 2024-04-06 22:02:08
JB062 is a nonmuscle myosin inhibitor with IC50 values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy[1].

Name	JB062

Description	JB062 is a nonmuscle myosin inhibitor with IC50 values of 1.6, 5.4, and >100 μM for Skeletal muscle myosin, Cardiac muscle myosin, and Smooth muscle myosin II, respectively. JB062 has cytotoxic to human cancer cells but not normal cells. JB062 can be used in research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy[1].
Related Catalog	Signaling Pathways >> Cytoskeleton >> Myosin Research Areas >> Neurological Disease
Target	IC50: 1.6 μM (Skeletal muscle myosin), 5.4 μM (Cardiac muscle myosin), and >100 μM (Smooth muscle myosin II)[1]
In Vitro	JB062 (compound 6b; 40 μM; 24 h) 抑制 COS-7 细胞的胞质分裂[1]。 JB062 (COS-7 细胞) 对人类癌细胞具有细胞毒性，但对正常细胞没有细胞毒性，CC10 值为 36 μM[1]。
References	[1]. Smith JD, et, al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2022 Dec 12;247:115008.

Molecular Formula	C₁₉H₁₇NO₄
Molecular Weight	323.34