862909-67-9
862909-67-9 structure
- Name: Epiboxidine hydrochloride
- Chemical Name: Epiboxidine hydrochloride
- CAS Number: 862909-67-9
- Molecular Formula: C10H15ClN2O
- Molecular Weight: 214.69
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
- Create Date: 2023-06-20 14:11:31
- Modify Date: 2024-01-10 16:05:55
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Epiboxidine hydrochloride is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine hydrochloride is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418[1].
| Name | Epiboxidine hydrochloride |
|---|
| Description | Epiboxidine hydrochloride is a potent and selective neural nAChR agonist with Kis of 0.46 nM and 1.2 nM for rat and human α4β2 nAChRs, respectively. Epiboxidine hydrochloride is a methylisoxazole analog of the alkaloid Epibatidine, and is also an analog of another nAChR agonist, ABT 418[1]. |
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| Related Catalog | |
| In Vitro | Epiboxidine hydrochloride 对中枢神经元 α4β2 受体具有亲和力和功能性，在大鼠和人体内的 Ki 分别为 0.46 和 1.2[1]。 Epiboxidine hydrochloride 对 PC12 细胞神经节型 α3β4*-烟碱样受体具有活性，Ki 为 19[1]。 Epiboxidine hydrochloride 的毒性远低于 Epibatidine[1]。 Epiboxidine hydrochloride 刺激 PC12 和 TE671 细胞中的 sodium-22 内流，EC50s 分别为 0.18 和 2.6 μM[2]。 |
| In Vivo | Epiboxidine hydrochloride（20 μg/kg；腹腔注射；一次）治疗在小鼠体内显示出显着的镇痛活性[1]。 Epiboxidine hydrochloride（50 和 100 mg/kg；腹膜内注射；一次）在热板试验中引起显着的抗伤害作用[2]。 Epiboxidine hydrochloride 抑制 [3H]尼古丁在大鼠大脑皮层膜中的结合，Ki 为 0.6 nM[2]。 |
| References |
| Molecular Formula | C10H15ClN2O |
|---|---|
| Molecular Weight | 214.69 |