871597-03-4

871597-03-4 structure

Name: Rosomidnar
Chemical Name: Rosomidnar
CAS Number: 871597-03-4
Molecular Formula: C₂₂₇H₂₉₁O₁₄₁P₂₃
Molecular Weight: 7220.63
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2023-05-31 20:37:56
Modify Date: 2024-04-03 04:23:11
PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.

Name	Rosomidnar

Description	PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer
References	[1]. Rodrigueza WV, Woolliscroft MJ, Ebrahim AS, et al. Development and antitumor activity of a BCL-2 targeted single-stranded DNA oligonucleotide. Cancer Chemother Pharmacol. 2014;74(1):151-166. [2]. Westin J, Maris MB, Jacobson CA, et al. Safety and Efficacy of a DNA Oligonucleotide Therapy in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymphoma. Clin Lymphoma Myeloma Leuk. 2022;22(1):52-59.

Molecular Formula	C₂₂₇H₂₉₁O₁₄₁P₂₃
Molecular Weight	7220.63