2848632-52-8

2848632-52-8 structure

Name: Antitumor agent-101
Chemical Name: Antitumor agent-101
CAS Number: 2848632-52-8
Molecular Formula: C₂₆H₃₈N₆O₃
Molecular Weight: 482.62
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2023-10-19 20:26:08
Modify Date: 2024-01-28 19:11:55
Antitumor agent-101 is a selective covalent inhibitor of lysine methyltransferases G9a/GLP, with IC50s of 8.5 nM and 5.5 nM for G9a and GLP, respectively. Antitumor agent-101 shows antitumor efficacy in the PANC-1 xenograft model[1].

Name	Antitumor agent-101

Description	Antitumor agent-101 is a selective covalent inhibitor of lysine methyltransferases G9a/GLP, with IC50s of 8.5 nM and 5.5 nM for G9a and GLP, respectively. Antitumor agent-101 shows antitumor efficacy in the PANC-1 xenograft model[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase
Target	G9a:8.5 nM (IC50) GLP:5.5 nM (IC50)
References	[1]. Feng Z, et.al. Structure-Based Design and Characterization of the Highly Potent and Selective Covalent Inhibitors Targeting the Lysine Methyltransferases G9a/GLP. J Med Chem. 2023 Jun 22;66(12):8086-8102.

Molecular Formula	C₂₆H₃₈N₆O₃
Molecular Weight	482.62