2632305-17-8

2632305-17-8 structure

Name: ARD-2051
Chemical Name: ARD-2051
CAS Number: 2632305-17-8
Molecular Formula: C₄₃H₄₅ClN₈O₅
Molecular Weight: 789.32
Catalog: Signaling Pathways PROTAC PROTAC
Create Date: 2023-09-18 18:29:04
Modify Date: 2024-01-13 16:47:50
ARD-2051 is a potent and orally active androgen receptor (AR) proteolysis-targeting chimera degrader. ARD-2051 achieves DC50 values of 0.6 nM for AR protein degradation in both the LNCaP and VCaP prostate cancer cell lines. ARD-2051 can be used for the research of prostate cancer[1].

Name	ARD-2051

Description	ARD-2051 is a potent and orally active androgen receptor (AR) proteolysis-targeting chimera degrader. ARD-2051 achieves DC50 values of 0.6 nM for AR protein degradation in both the LNCaP and VCaP prostate cancer cell lines. ARD-2051 can be used for the research of prostate cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Signaling Pathways >> Others >> Androgen Receptor
Target	DC50: 0.6 nM (AR protein degradation)[1]
References	[1]. Han X, et al. Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer. J Med Chem. 2023 Jul 13;66(13):8822-8843.

Molecular Formula	C₄₃H₄₅ClN₈O₅
Molecular Weight	789.32