2770009-06-6

2770009-06-6 structure

Name: EGFR mutant-IN-2
Chemical Name: EGFR mutant-IN-2
CAS Number: 2770009-06-6
Molecular Formula: C₂₇H₂₇F₃N₆O₂S
Molecular Weight: 556.60
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2023-11-25 16:53:16
Modify Date: 2024-01-22 17:44:01
EGFR mutant-IN-2 (Compound D51) is an EGFR mutant inhibitor. EGFR mutant-IN-2 inhibits the EGFRL858R/T790M/C797S mutant with an IC50 value of 14 nM. EGFR mutant-IN-2 inhibits the EGFRdel19/T790M/C797S mutant with an IC50 value of 62 nM. EGFR mutant-IN-2 has favorable PK parameters, safety properties, in vivo stability, and antitumor activity[1].

Name	EGFR mutant-IN-2

Description	EGFR mutant-IN-2 (Compound D51) is an EGFR mutant inhibitor. EGFR mutant-IN-2 inhibits the EGFRL858R/T790M/C797S mutant with an IC50 value of 14 nM. EGFR mutant-IN-2 inhibits the EGFRdel19/T790M/C797S mutant with an IC50 value of 62 nM. EGFR mutant-IN-2 has favorable PK parameters, safety properties, in vivo stability, and antitumor activity[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
References	[1]. Dong H, et al. Discovery of Potent and Wild-Type-Sparing Fourth-Generation EGFR Inhibitors for Treatment of Osimertinib-Resistance NSCLC. J Med Chem. 2023 May 25;66(10):6849-6868.

Molecular Formula	C₂₇H₂₇F₃N₆O₂S
Molecular Weight	556.60