1422456-47-0

1422456-47-0 structure

Name: FD1024
Chemical Name: FD1024
CAS Number: 1422456-47-0
Molecular Formula: C₂₁H₂₀F₂N₄O₂S
Molecular Weight: 430.47
Catalog: Signaling Pathways JAK/STAT Signaling Pim
Create Date: 2023-09-17 12:29:25
Modify Date: 2024-01-20 15:55:29
FD1024 is PIM inhibitor (IC50s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3). FD1024 can be used for research of acute myeloid leukemia. FD1024 has strong antiproliferative activity against the tested AML cell lines, with 0.16 μM, 0.12 μM, 1.05 μM, 1.39μM for EOL-1, MV-4-11, KG-1, MOLM-16 cells. FD1024 also has antitumor efficacy in mice[1].

Name	FD1024

Description	FD1024 is PIM inhibitor (IC50s: 1.96, 38.9, 4.17 nM for PIM1, 2, 3). FD1024 can be used for research of acute myeloid leukemia. FD1024 has strong antiproliferative activity against the tested AML cell lines, with 0.16 μM, 0.12 μM, 1.05 μM, 1.39μM for EOL-1, MV-4-11, KG-1, MOLM-16 cells. FD1024 also has antitumor efficacy in mice[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> Pim
Target	1.96, 38.9, 4.17 nM for PIM1, 2, 3[1]
References	[1]. Xiang R, et al. Discovery of a high potent PIM kinase inhibitor for acute myeloid leukemia based on N-pyridinyl amide scaffold by optimizing the fragments toward to Lys67 and Asp128/Glu171. Eur J Med Chem. 2023 Sep 5;257:115514.

Molecular Formula	C₂₁H₂₀F₂N₄O₂S
Molecular Weight	430.47