28532-21-0

28532-21-0 structure

Name: MC4033
Chemical Name: MC4033
CAS Number: 28532-21-0
Molecular Formula: C₁₆H₁₃N₃O₃
Molecular Weight: 295.29
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2023-09-23 21:50:25
Modify Date: 2024-09-16 11:09:51
MC4033 shows IC50s of 39.4 μM, 52.1 μM, 41 μM and 30.1 μM in HCT116, H1299, A549 and U937, respectively[1]. MC4033 (25, 50, 100, and 200 μM, 72 h) reduces the level of H4K16Ac in HT29 cells, suggesting its ability to inhibit KAT8 in cells[1].

Name	MC4033

Description	MC4033 shows IC50s of 39.4 μM, 52.1 μM, 41 μM and 30.1 μM in HCT116, H1299, A549 and U937, respectively[1]. MC4033 (25, 50, 100, and 200 μM, 72 h) reduces the level of H4K16Ac in HT29 cells, suggesting its ability to inhibit KAT8 in cells[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Epigenetics >> Histone Acetyltransferase
Target	12.1μM (lysine acetyltransferase 8, KAT8)[1]
References	[1]. Fiorentino F, et al. First-in-Class Selective Inhibitors of the Lysine Acetyltransferase KAT8. J Med Chem. 2023 May 25;66(10):6591-6616

Molecular Formula	C₁₆H₁₃N₃O₃
Molecular Weight	295.29