891198-31-5

891198-31-5 structure

Name: RXP470.1
Chemical Name: RXP470.1
CAS Number: 891198-31-5
Molecular Formula: C₃₅H₃₅BrClN₄O₁₀P
Molecular Weight: 818.00
Catalog: Signaling Pathways Metabolic Enzyme/Protease MMP
Create Date: 2024-01-01 11:08:31
Modify Date: 2024-01-01 11:08:31
RXP470.1 (RXP-470) is a potent, selective MMP-12 inhibitor with a Ki of 0.2 nM against human MMP-12. RXP470.1 is 2 to 4 orders of magnitude less potent against other MMPs. RXP470.1 significantly reduces atherosclerotic plaque cross-sectional area in mouse. RXP470.1 results in less complex plaques with increased smooth muscle cell:macrophage ratio, less macrophage apoptosis, increased cap thickness, smaller necrotic cores, and decreased incidence of calcification[1].

Name	RXP470.1

Description	RXP470.1 (RXP-470) is a potent, selective MMP-12 inhibitor with a Ki of 0.2 nM against human MMP-12. RXP470.1 is 2 to 4 orders of magnitude less potent against other MMPs. RXP470.1 significantly reduces atherosclerotic plaque cross-sectional area in mouse. RXP470.1 results in less complex plaques with increased smooth muscle cell:macrophage ratio, less macrophage apoptosis, increased cap thickness, smaller necrotic cores, and decreased incidence of calcification[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
Target	human MMP-12:0.2 nM (Ki)
References	[1]. Jason L Johnson, et al. A selective matrix metalloproteinase-12 inhibitor retards atherosclerotic plaque development in apolipoprotein E-knockout mice. Arterioscler Thromb Vasc Biol. 2011 Mar;31(3):528-35.

Molecular Formula	C₃₅H₃₅BrClN₄O₁₀P
Molecular Weight	818.00