2927557-06-8

2927557-06-8 structure

Name: SIKs-IN-1
Chemical Name: SIKs-IN-1
CAS Number: 2927557-06-8
Molecular Formula: C₂₇H₃₁F₂N₇O
Molecular Weight: 507.58
Catalog: Signaling Pathways Immunology/Inflammation Salt-inducible Kinase (SIK)
Create Date: 2023-09-20 17:02:44
Modify Date: 2024-01-07 00:31:00
SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model[1].

Name	SIKs-IN-1

Description	SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> Salt-inducible Kinase (SIK)
References	[1]. Cai X, et al. Discovery of pyrimidine-5-carboxamide derivatives as novel salt-inducible kinases (SIKs) inhibitors for inflammatory bowel disease (IBD) treatment. Eur J Med Chem. 2023 Aug 5;256:115469.

Molecular Formula	C₂₇H₃₁F₂N₇O
Molecular Weight	507.58