547741-78-6

547741-78-6 structure

Name: α-Conotoxin GID
Chemical Name: α-Conotoxin GID
CAS Number: 547741-78-6
Molecular Formula: C₈₄H₁₃₂N₃₀O₃₁S₄
Molecular Weight: 2186.39
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2023-11-11 21:38:37
Modify Date: 2024-01-02 15:31:59
α-Conotoxin GID is a paralytic peptide neurotoxin and a selective antagonist of nAChR, with IC50s of 5 nM (α7), 3 nM (α3β2)， 150 nM (α4β2), respectively. α-Conotoxin GID is small disulfide-rich peptide, with potential to inhibit chronic pain. α-Conotoxin GID contains a C-terminal carboxylate, thus substitution with a C-terminal carboxamide results in loss of α4β2 nAChR. α-Conotoxin GID can be isolated from the Conus species[1][2][3].

Name	α-Conotoxin GID

Description	α-Conotoxin GID is a paralytic peptide neurotoxin and a selective antagonist of nAChR, with IC50s of 5 nM (α7), 3 nM (α3β2)， 150 nM (α4β2), respectively. α-Conotoxin GID is small disulfide-rich peptide, with potential to inhibit chronic pain. α-Conotoxin GID contains a C-terminal carboxylate, thus substitution with a C-terminal carboxamide results in loss of α4β2 nAChR. α-Conotoxin GID can be isolated from the Conus species[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
Target	IC50: 5 nM (α7), 3 nM (α3β2)， 150 nM (α4β2)[1]
References	[1]. Armishaw CJ. Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leads. Toxins (Basel). 2010 Jun;2(6):1471-99. [2]. Millard EL, et al. Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. J Biol Chem. 2009 Feb 20;284(8):4944-51. [3]. Nicke A, et al. Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. J Biol Chem. 2003 Jan 31;278(5):3137-44.

Molecular Formula	C₈₄H₁₃₂N₃₀O₃₁S₄
Molecular Weight	2186.39