2295804-68-9
2295804-68-9 structure
- Name: FXR antagonist 1
- Chemical Name: FXR antagonist 1
- CAS Number: 2295804-68-9
- Molecular Formula: C36H59NO5
- Molecular Weight: 585.87
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FXR antagonist 1 is a selective, orally active intestinal FXR antagonist with an IC50 value of 2.1 μM. FXR antagonist 1 antagonises intestinal FXR and selectively inhibits intestinal FXR signalling by feedback activation of hepatic FXR. FXR antagonist 1 can improve liver steatosis, inflammation and fibrosis in the NASH (non-alcoholic steatohepatitis) model and can be used to study NASH.
| Name | FXR antagonist 1 |
|---|
| Description | FXR antagonist 1 is a selective, orally active intestinal FXR antagonist with an IC50 value of 2.1 μM. FXR antagonist 1 antagonises intestinal FXR and selectively inhibits intestinal FXR signalling by feedback activation of hepatic FXR. FXR antagonist 1 can improve liver steatosis, inflammation and fibrosis in the NASH (non-alcoholic steatohepatitis) model and can be used to study NASH. |
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| Molecular Formula | C36H59NO5 |
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| Molecular Weight | 585.87 |