- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Sodium cholate
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Yang
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Sodium cholate
- Price: ￥658.0/100g ￥78.0/5g ￥218.0/25g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Liu jia
206986-87-0
206986-87-0 structure
- Name: Sodium cholate
- Chemical Name: sodium,(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate,hydrate
- CAS Number: 206986-87-0
- Molecular Formula: C24H39NaO5
- Molecular Weight: 430.553
- Catalog: analytical chemistry Analytical reagent Common analytical reagents
- Create Date: 2018-03-05 08:00:00
- Modify Date: 2024-01-03 18:32:39
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Cholic acid sodium hydrate is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid sodium hydrate facilitates fat absorption and cholesterol excretion. Cholic acid sodium hydrate is orally active[1][2].
| Name | sodium,(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate,hydrate |
|---|---|
| Synonyms |
Sodium (4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
Cholan-24-oic acid, 3,7,12-trihydroxy-, sodium salt, (3α,5β,7α,12α)- (1:1) cholan-24-oic acid, 3,7,12-trihydroxy-, monosodium salt, (3α,5β,7α,8ξ,12α)- (3α,5β,7α,8ξ,12α)-3,7,12-Trihydroxycholan-24-oate de sodium Cholan-24-oic acid, 3,7,12-trihydroxy-, monosodium salt, (3α,5β,7α,12α)- EINECS 206-643-5 Sodium (3α,5β,7α,12α)-3,7,12-trihydroxycholan-24-oate Natrium-(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxycholan-24-oat (4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-diméthylhexadécahydro-1H-cyclopenta[a]phénanthrén-17-yl]pentanoate de sodium Natrium-(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoat 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oic acid sodium salt MFCD00064138 cholan-24-oic acid, 3,7,12-trihydroxy-, sodium salt, (3α,5β,7α,8ξ,12α)- (1:1) Sodium cholate Sodium cholate hydrate (3α,5β,7α,12α)-3,7,12-Trihydroxycholan-24-oic acid sodium salt Cholalic acid sodium salt Sodium (3α,5β,7α,8ξ,12α)-3,7,12-trihydroxycholan-24-oate |
| Description | Cholic acid sodium hydrate is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid sodium hydrate facilitates fat absorption and cholesterol excretion. Cholic acid sodium hydrate is orally active[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway[1]. |
| In Vivo | Cholic acid (1% (w/w) Cholic acid-supplemented diet; p.o.; 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity[2]. Animal Model: Tg-CYP2D6 adult male mice (8 weeks of age and weighing 20–25 g)[2] Dosage: 1% (w/w) Cholic acid-supplemented diet Administration: Oral, 14 days Result: Decreases SHP expression and increased CYP2D6 activity. |
| References |
| Molecular Formula | C24H39NaO5 |
|---|---|
| Molecular Weight | 430.553 |
| Exact Mass | 430.269531 |
| PSA | 100.82000 |
| LogP | 2.11400 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2918290000 |
| HS Code | 2918290000 |
|---|---|
| Summary | HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0% |