2648450-42-2

2648450-42-2 structure

Name: GNE-7883
Chemical Name: GNE-7883
CAS Number: 2648450-42-2
Molecular Formula: C₂₈H₂₉FN₆O₂
Molecular Weight: 500.57
Catalog: Signaling Pathways Stem Cell/Wnt YAP
Create Date: 2023-10-26 17:48:56
Modify Date: 2024-01-02 12:07:15
GNE-7883 is a pan-TEAD inhibitor with anti-cell proliferation activity. GNE-7883 overcomes resistance to KRAS G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation. GNE-7883 may be used in the study of YAP/TAZ-dependent cancers[1].

Name	GNE-7883

Description	GNE-7883 is a pan-TEAD inhibitor with anti-cell proliferation activity. GNE-7883 overcomes resistance to KRAS G12C inhibitors in multiple preclinical models by inhibiting YAP/TAZ activation. GNE-7883 may be used in the study of YAP/TAZ-dependent cancers[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Stem Cell/Wnt >> YAP
Target	TEAD[1].
References	[1]. Hagenbeek TJ, et al. An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance. Nat Cancer. 2023 Jun;4(6):812-828.

Molecular Formula	C₂₈H₂₉FN₆O₂
Molecular Weight	500.57