Shanghai Nianxing Industrial Co., Ltd
China
Product Name: mTOR inhibitor-13
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1144075-44-4

1144075-44-4 structure

1144075-44-4 structure

Name: mTOR inhibitor-13
Chemical Name: mTOR inhibitor-13
CAS Number: 1144075-44-4
Molecular Formula: C₂₄H₂₂N₆O₂S
Molecular Weight: 458.54
Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
Create Date: 2023-11-18 15:24:22
Modify Date: 2024-04-13 11:41:14
mTOR inhibitor-13 (compound 9g), an aryl ureido compound, is a potent and selective mTOR inhibitor with an IC50 of 0.29 nM. mTOR inhibitor-13 also inhibits PI3K-α with an IC50 of 119 nM[1].

Name	mTOR inhibitor-13

Description	mTOR inhibitor-13 (compound 9g), an aryl ureido compound, is a potent and selective mTOR inhibitor with an IC50 of 0.29 nM. mTOR inhibitor-13 also inhibits PI3K-α with an IC50 of 119 nM[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	mTOR:0.29 nM (IC50) PI3Kα:119 nM (IC50)
References	[1]. Jeroen C Verheijen, et al. Discovery of 2-arylthieno[3,2-d]pyrimidines containing 8-oxa-3-azabi-cyclo[3.2.1]octane in the 4-position as potent inhibitors of mTOR with selectivity over PI3K. Bioorg Med Chem Lett. 2010 Jan 1;20(1):375-9.

Molecular Formula	C₂₄H₂₂N₆O₂S
Molecular Weight	458.54