Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Pachycarpine
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Pachycarpine
Price: ￥118.0/500mg ￥217.0/1g ￥618.0/5g ￥1888.0/25g
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Pachycarpine
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492-08-0

492-08-0 structure

492-08-0 structure

Name: Pachycarpine
Chemical Name: (+)-Sparteine
CAS Number: 492-08-0
Molecular Formula: C₁₅H₂₆N₂
Molecular Weight: 234.380
Catalog: API Circulatory system medication Antiarrhythmic drug
Create Date: 2018-07-21 18:07:13
Modify Date: 2024-01-03 09:09:27
(+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons.

Name	(+)-Sparteine
Synonyms	[7S-(7a,7aa,14a,14ab)]-Dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine [7S-(7α,7aα,14α,14aβ)]-Dodecahydro-7,14-methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine (1S,2R,9S,10S)-7,15-Diazatetracyclo[7.7.1.0.0]heptadecane Sparteine, (+)-Isomer lupinidine sparteine Pachycarpine (7α,9α)-Sparteine 7,14-Methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine, dodecahydro-, (7R,7aR,14R,14aS)- 7,14-Methano-2H,6H-dipyrido[1,2-a:1',2'-e][1,5]diazocine, dodecahydro-, (7S,7aR,14S,14aS)-

Description	(+)-Sparteine is a natural alkaloid acting as a ganglionic blocking agent. (+)-Sparteine competitively blocks nicotinic ACh receptor in the neurons.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Natural Products >> Alkaloid Research Areas >> Neurological Disease
Target	AChR[1]
In Vitro	(+)-Sparteine (2 μM) reduces the ACh-induced current caused by activation of nicotinic AChRs in a voltage-independent manner. (+)-Sparteine (5, 10 μM) reduces the amplitude of the excitatory postsynaptic current (EPSC) and the time constant of the EPSC decay[1].
References	[1]. Voitenko S, et al. Effect of (+)-sparteine on nicotinic acetylcholine receptors in the neurons of rat superior cervical ganglion. Mol Pharmacol. 1991 Aug;40(2):180-5.

Density	1.1±0.1 g/cm3
Boiling Point	340.9±10.0 °C at 760 mmHg
Melting Point	201ºC
Molecular Formula	C₁₅H₂₆N₂
Molecular Weight	234.380
Flash Point	148.3±6.8 °C
Exact Mass	234.209595
PSA	6.48000
LogP	3.21
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.570

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RT0620000

CHEMICAL NAME :: Pachycarpine

CAS REGISTRY NUMBER :: 492-08-0

BEILSTEIN REFERENCE NO. :: 3540601

LAST UPDATED :: 199709

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H26-N2

MOLECULAR WEIGHT :: 234.43

WISWESSER LINE NOTATION :: T C66 K66 A HN PNTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 89100 ug/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: SHIYDO Shaanxi Xinyiyao. Shaanxi New Medical. (Shaanxi Renmin Chubanshe, Xi'an, Shaanxi, Peop. Rep. China) V.1- 1972- Volume(issue)/page/year: 11(6),53,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 21(5),46,1958

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 26 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 32ZCAI "Ganglion-Blocking and Ganglion-Stimulation Agents," Kharkevich, D.A., Moscow, First Moscow Medical Institute, 1967 Volume(issue)/page/year: -,175,1967

Hazard Codes	Xi
RTECS	RT0620000