212779-48-1

212779-48-1 structure

Name: NG 52
Chemical Name: 2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol
CAS Number: 212779-48-1
Molecular Formula: C₁₆H₁₉ClN₆O
Molecular Weight: 346.815
Catalog: Research Areas Cancer
Create Date: 2017-11-28 09:50:34
Modify Date: 2024-01-31 21:40:52
NG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM).IC50 value: 7 uM [1]Target: Cdc28pCompound 52 inhibited growth in a drug-sensitized yeast strainwith a GI 50 of 30 uM. In contrast, the closely related compound 52Me proved to be a significantly weaker inhibitor of yeast growth (GI50=200 uM).

Name	2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol
Synonyms	Ethanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]- 2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine NG-52 OLP 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE compound 52 2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanol 3bpr 2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)ethanol NG-52 NG 52

Description	NG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM).IC50 value: 7 uM [1]Target: Cdc28pCompound 52 inhibited growth in a drug-sensitized yeast strainwith a GI 50 of 30 uM. In contrast, the closely related compound 52Me proved to be a significantly weaker inhibitor of yeast growth (GI50=200 uM).
Related Catalog	Research Areas >> Cancer
Target	cdc2-cyclin B:0.34 μM (IC50) Pho85p:2 nM (IC50)
References	[1]. ray NS, Wodicka L, Thunnissen AM et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8.