1335113-30-8

1335113-30-8 structure

Name: EBOV-IN-1
Chemical Name: EBOV-IN-1
CAS Number: 1335113-30-8
Molecular Formula: C₃₄H₄₃N₃O₅
Molecular Weight: 573.72
Catalog: Signaling Pathways Anti-infection Filovirus
Create Date: 2024-01-12 18:34:44
Modify Date: 2024-01-12 18:34:44
EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM[1].

Name	EBOV-IN-1

Description	EBOV-IN-1 (com 3.47) is an adamantane dipeptide piperazine and an inhibitor of Ebola virus (EBOV). EBOV-IN-1 targets Niemann-Pick C1 (NPC1) and inhibits its binding to the EBOV glycoprotein (GP) that activates and mediates viral penetration into host cells, thereby inhibiting EBOV infection. EBOV-IN-1 inhibits pseudotyped EBOV infection with an IC50 of 13 nM[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Filovirus
References	[1]. Liu H, et al. Identification of Potent Ebola Virus Entry Inhibitors with Suitable Properties for in Vivo Studies. J Med Chem. 2018 Jul 26;61(14):6293-6307.

Molecular Formula	C₃₄H₄₃N₃O₅
Molecular Weight	573.72