2413029-40-8

2413029-40-8 structure

2413029-40-8 structure

Name: EGFR-IN-89
Chemical Name: EGFR-IN-89
CAS Number: 2413029-40-8
Molecular Formula: C₂₆H₃₁FN₈O₂S
Molecular Weight: 538.64
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2024-01-08 12:34:23
Modify Date: 2024-01-08 12:34:23
EGFR-IN-89 (compound 13k) is a potent, fourth-generation EGFR mutation inhibitor with an IC50 of 10.1 nM against Del19/T790M/C797S mutations. EGFR-IN-89 shows higher selectivity over wild type[1].

Name	EGFR-IN-89

Description	EGFR-IN-89 (compound 13k) is a potent, fourth-generation EGFR mutation inhibitor with an IC50 of 10.1 nM against Del19/T790M/C797S mutations. EGFR-IN-89 shows higher selectivity over wild type[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
Target	EGFR19del/TM/CS:10.1 nM (IC50)
References	[1]. Jiyoung Jeon, et al. Design and synthesis of 4th generation EGFR inhibitors against human triple (Del19/T790M/C797S) mutation. Eur J Med Chem. 2023 Sep 27:261:115840.

Molecular Formula	C₂₆H₃₁FN₈O₂S
Molecular Weight	538.64