2642327-44-2

2642327-44-2 structure

Name: PAD4-IN-3
Chemical Name: PAD4-IN-3
CAS Number: 2642327-44-2
Molecular Formula: C₂₁H₂₆BClN₄O₄
Molecular Weight: 444.72
Catalog: Research Areas Cancer
Create Date: 2023-12-24 15:46:24
Modify Date: 2024-01-22 20:21:27
PAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment[1].

Name	PAD4-IN-3

Description	PAD4-IN-3 (compound 4B) is a PAD4 inhibitor with antitumor activity in vitro and in vivo. PAD4-IN-3 was covalently linked to RGD sequence peptide-modified chitosan (K-CRGDV), resulting in an enhanced oxidative stress-responsive nanoagent. K-CRGDV-PAD4-IN-3 can actively target tumors, inhibit PAD4 activity, block the formation of neutrophil extracellular traps (NETs), and improve the tumor immune microenvironment in response to the tumor microenvironment[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Protein Arginine Deiminase
Target	PAD4[1]
References	[1]. Jia Y et al. Chitosan nanomedicine containing RGD peptide and PAD4 inhibitor based on phenyl boronate coupling inhibition of primary tumor growth and lung metastasis. Biomed Pharmacother. 2023 Dec;168:115826.

Molecular Formula	C₂₁H₂₆BClN₄O₄
Molecular Weight	444.72