2756228-76-7

2756228-76-7 structure
2756228-76-7 structure
  • Name: Riliprubart
  • Chemical Name: Riliprubart
  • CAS Number: 2756228-76-7
  • Molecular Formula:
  • Molecular Weight:
  • Catalog: Signaling Pathways Immunology/Inflammation Complement System
  • Create Date: 2024-01-01 17:46:05
  • Modify Date: 2024-01-01 17:46:05
  • Riliprubart (SAR445088) is an anti-C1s humanized monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system. Riliprubart selectively inhibits activated C1s and prevents the enzymatic action of C1 on its substrates C4 and C2, thus inhibiting the formation of the classical pathway C3 convertase, C4b2a[1].

Name Riliprubart
Description Riliprubart (SAR445088) is an anti-C1s humanized monoclonal antibody that inhibits activated C1s in the proximal portion of the classical complement system. Riliprubart selectively inhibits activated C1s and prevents the enzymatic action of C1 on its substrates C4 and C2, thus inhibiting the formation of the classical pathway C3 convertase, C4b2a[1].
Related Catalog
References

[1]. Timothy Chow, et al. First-in-human study with SAR445088: A novel selective classical complement pathway inhibitor. Clin Transl Sci. 2023 Apr;16(4):673-685.  

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