2802453-88-7

2802453-88-7 structure

Name: SHP2-IN-22
Chemical Name: SHP2-IN-22
CAS Number: 2802453-88-7
Molecular Formula: C₂₃H₂₂Cl₂N₈O
Molecular Weight: 497.38
Catalog: Research Areas Cancer
Create Date: 2024-02-10 19:18:35
Modify Date: 2024-02-10 19:18:35
SHP2-IN-22 is SHP2 allosteric inhibitor with an IC50 value of 17.7 nM. SHP2-IN-22 inhibits the proliferation, migration, and invasion of MIA PaCa-2 pancreatic cancer cells. SHP2-IN-22 can be used for Kirsten rat sarcoma viral oncogene (KRAS) mutant cancer research[1].

Name	SHP2-IN-22

Description	SHP2-IN-22 is SHP2 allosteric inhibitor with an IC50 value of 17.7 nM. SHP2-IN-22 inhibits the proliferation, migration, and invasion of MIA PaCa-2 pancreatic cancer cells. SHP2-IN-22 can be used for Kirsten rat sarcoma viral oncogene (KRAS) mutant cancer research[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Hou Q, et al. Identification of a Novel, Potent, and Orally Bioavailable Guanidine-Based SHP2 Allosteric Inhibitor from Virtual Screening and Rational Structural Optimization for the Treatment of KRAS Mutant Cancers. J Med Chem. 2023 Oct 12;66(19):13646-13664.

Molecular Formula	C₂₃H₂₂Cl₂N₈O
Molecular Weight	497.38