SHP2-IN-22

Modify Date: 2024-02-10 19:18:35

SHP2-IN-22 structure	Common Name	SHP2-IN-22
	CAS Number	2802453-88-7	Molecular Weight	497.38
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₂Cl₂N₈O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SHP2-IN-22

SHP2-IN-22 is SHP2 allosteric inhibitor with an IC50 value of 17.7 nM. SHP2-IN-22 inhibits the proliferation, migration, and invasion of MIA PaCa-2 pancreatic cancer cells. SHP2-IN-22 can be used for Kirsten rat sarcoma viral oncogene (KRAS) mutant cancer research[1].

Name	SHP2-IN-22

Description	SHP2-IN-22 is SHP2 allosteric inhibitor with an IC50 value of 17.7 nM. SHP2-IN-22 inhibits the proliferation, migration, and invasion of MIA PaCa-2 pancreatic cancer cells. SHP2-IN-22 can be used for Kirsten rat sarcoma viral oncogene (KRAS) mutant cancer research[1].
Related Catalog	Research Areas >> Cancer
References	[1]. Hou Q, et al. Identification of a Novel, Potent, and Orally Bioavailable Guanidine-Based SHP2 Allosteric Inhibitor from Virtual Screening and Rational Structural Optimization for the Treatment of KRAS Mutant Cancers. J Med Chem. 2023 Oct 12;66(19):13646-13664.

Molecular Formula	C₂₃H₂₂Cl₂N₈O
Molecular Weight	497.38

SHP2-IN-22

Use of SHP2-IN-22

Names

SHP2-IN-22 Biological Activity

Chemical & Physical Properties