117038-80-9

117038-80-9 structure

Name: licopyranocoumarin
Chemical Name: 3-(2,4-Dihydroxyphenyl)-8-(hydroxymethyl)-5-methoxy-8-methyl-7,8- dihydro-2H,6H-pyrano[3,2-g]chromen-2-one
CAS Number: 117038-80-9
Molecular Formula: C₂₁H₂₀O₇
Molecular Weight: 384.37900
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2016-08-22 02:52:00
Modify Date: 2024-01-05 19:12:56
Licopyranocoumarin is an isoflavonoid that shows CYP3A4 inhibitory activity with an IC50 of 32 μM. Licopyranocoumarin has potent neuroprotective activities[1].

Name	3-(2,4-Dihydroxyphenyl)-8-(hydroxymethyl)-5-methoxy-8-methyl-7,8- dihydro-2H,6H-pyrano[3,2-g]chromen-2-one
Synonyms	IB-MECA 3-IB-Meca CF 101

Description	Licopyranocoumarin is an isoflavonoid that shows CYP3A4 inhibitory activity with an IC50 of 32 μM. Licopyranocoumarin has potent neuroprotective activities[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Neurological Disease
Target	CYP3A4:32 μM (IC50)
In Vitro	Licopyranocoumarin（0.3-3 μM；48 小时）显着阻断 MPP+ 诱导的神经元 PC12D 细胞死亡和线粒体膜电位消失，这是由 JNK[1] 介导的。 Licopyranocoumarin（0.3-3 μM；36 小时）通过抑制活性氧 (ROS) 的生成来抑制 MPP+ 诱导的 JNK 活化，从而抑制 MPP+ 诱导的神经元 PC12D 细胞死亡[1]。 Cell Viability Assay[1] Cell Line: PC12D cell Concentration: 0.3 μM, 1 μM, 3 μM Incubation Time: 48 hours Result: Inhibited MPP+-induced cell death. Western Blot Analysis[1] Cell Line: PC12D cell Concentration: 0.3 μM, 1 μM, 3 μM Incubation Time: 36 hours Result: Attenuated JNK activity induced by MPP+.
References	[1]. Takahiro Fujimaki, et al. Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease. PLoS One. 2014 Jun 24;9(6):e100395. [2]. Sachiko Tsukamoto, et al. CYP3A4 inhibitors isolated from Licorice. Biol Pharm Bull. 2005 Oct;28(10):2000-2.

Hazard Codes	Xi