88349-90-0
88349-90-0 structure
- Name: A2793
- Chemical Name: ethyl 2-(5-chloroquinolin-8-yl)oxyacetate
- CAS Number: 88349-90-0
- Molecular Formula: C13H12ClNO3
- Molecular Weight: 265.69200
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2016-04-09 19:50:59
- Modify Date: 2024-01-05 12:32:15
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A2793 is an efficient TWIK-related acid-sensitive K+ channel (TASK)-1 inhibitor, with an IC50 of 6.8 μM[1].
| Name | ethyl 2-(5-chloroquinolin-8-yl)oxyacetate |
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| Synonyms | MFCD04275530 |
| Description | A2793 is an efficient TWIK-related acid-sensitive K+ channel (TASK)-1 inhibitor, with an IC50 of 6.8 μM[1]. |
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| Related Catalog | |
| In Vitro | A2793 (100 µM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5)[1]. A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1[1]. |
| References |
| Density | 1.291±0.06 g/cm3 |
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| Boiling Point | 393.4±27.0 °C |
| Molecular Formula | C13H12ClNO3 |
| Molecular Weight | 265.69200 |
| Exact Mass | 265.05100 |
| PSA | 48.42000 |
| LogP | 2.83010 |
| Storage condition | -20°C |
| Hazard Codes | Xn |
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