19941-83-4

19941-83-4 structure

Name: Kolavenol
Chemical Name: Kolavenol
CAS Number: 19941-83-4
Molecular Formula: C₂₀H₃₄O
Molecular Weight: 290.48
Catalog: Natural product Moss
Create Date: 2017-02-09 21:03:02
Modify Date: 2024-01-08 15:41:35
Kolavenol can be isolated from the root of Solidago altissima L. Kolavenol enantiomer has trypanocidal activity against Trypanosoma brucei rhodesiense, the causative agent of the acute form of human African trypanosomiasis, with an IC50 of 2.5 μg/ml (8.6 μM)[1][2].

Name	Kolavenol
Synonyms	(2E)-3-Methyl-5-[(1S,2R,4aR,8aR)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydro-1-naphthalenyl]-2-penten-1-ol (2E)-3-methyl-5-[(1S,2R,4aR,8aR)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl]pent-2-en-1-ol 2-Penten-1-ol, 3-methyl-5-[(1S,2R,4aR,8aR)-1,2,3,4,4a,7,8,8a-octahydro-1,2,4a,5-tetramethyl-1-naphthalenyl]-, (2E)-

Description	Kolavenol can be isolated from the root of Solidago altissima L. Kolavenol enantiomer has trypanocidal activity against Trypanosoma brucei rhodesiense, the causative agent of the acute form of human African trypanosomiasis, with an IC50 of 2.5 μg/ml (8.6 μM)[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Kusumoto S, et al. The Structure and the Stereochemistry of Solidagonic Acid[J]. Bulletin of the Chemical Society of Japan, 1969, 42(3): 812-820. [2]. Freiburghaus F, et al. Bioassay-guided isolation of a diastereoisomer of kolavenol from Entada abyssinica active on Trypanosoma brucei rhodesiense. J Ethnopharmacol. 1998 Jul;61(3):179-83.