81-55-0

81-55-0 structure

Name: 1,8-Dihydroxy-4,5-dinitroanthraquinone
Chemical Name: 1,8-Dihydroxy-4,5-dinitroanthraquinone
CAS Number: 81-55-0
Molecular Formula: C₁₄H₆N₂O₈
Molecular Weight: 330.206
Catalog: Chemical reagent Organic reagent Tricyclic compound
Create Date: 2019-02-17 09:18:11
Modify Date: 2024-01-03 10:07:15
1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM[1].

Name	1,8-Dihydroxy-4,5-dinitroanthraquinone
Synonyms	4,5-Dinitrochrysazin 1,8 DIHYDROXY 4,5 DINITRO AQ 4,5-Dinitrodanthron 1,8-dihydroxy-4,5-dinitroanthra-9,10-quinone 1,8-dihydroxy-4,5-dinitro-anthraquinon Dihydroxy-4,5-dinitroanthraquinone MFCD00019149 1,8-Dihydroxy-4,5-dinitroanthracene-9,10-dione 1,8-Dihydroxy-4,5-dinitro-anthrachinon 1,8-dihydroxy-4,5-dinitro-anthraquinone 1,8-dihydroxy-4,5-dinitro-9,10-anthracenedione EINECS 201-360-3 1,8-Dihydroxy-4,5-dinitro-9,10-anthraquinone 1,8-Dihydroxy-4,5-di 9,10-Anthracenedione, 1,8-dihydroxy-4,5-dinitro- 4,5 DINITROCHRYSAZINE 4,5-dinitro-1,8-dihydroxyanthraquinone

Description	1,8-Dihydroxy-4,5-dinitroanthraquinone (ARDP0006; DHDNE) is a potent inhibitor of serine proteinase NS2B/3, the dengue viral protein. 1,8-Dihydroxy-4,5-dinitroanthraquinone has intermolecular proteinase activity and viral inhibition ability with IC50s of 432 μM and 4.2 μM, respectively. Meanwhile 1,8-Dihydroxy-4,5-dinitroanthraquinone inhibits NS2B/3 cleavage in BHK-21 cells at a dose ranging from 4.2 μM to 432 μM[1].
Related Catalog	Research Areas >> Infection
In Vitro	1,8-Dihydroxy-4,5-dinitroanthraquinone (50 μM-2 mM；90 分钟) 抑制 NS2B/3 裂解，并在 100 μM 时显着且显着地作用于 BHK-21 细胞[1]。
References	[1]. Constant DA, et al. Targeting intramolecular proteinase NS2B/3 cleavages for trans-dominant inhibition of dengue virus. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10136-10141.

Density	1.8±0.1 g/cm3
Boiling Point	669.4±55.0 °C at 760 mmHg
Melting Point	225 °C (dec.)(lit.)
Molecular Formula	C₁₄H₆N₂O₈
Molecular Weight	330.206
Flash Point	280.8±20.0 °C
Exact Mass	330.012421
PSA	166.24000
LogP	4.94
Vapour Pressure	0.0±2.1 mmHg at 25°C
Index of Refraction	1.782
Stability	Stable. Incompatible with strong oxidizing agents.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl 9),1,1987

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	CB6700000
HS Code	2914700090

117-10-2

~73%

81-55-0

Literature: Chang; Cheng Synthetic Communications, 1995 , vol. 25, # 13 p. 1893 - 1900

117-10-2

~76%

81-55-0

39003-36-6

Literature: Chang Synthetic Communications, 1994 , vol. 24, # 7 p. 931 - 937

HS Code	2914700090
Summary	HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%