340821-13-8

340821-13-8 structure

Name: (D-Phe5,Cys6.11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide
Chemical Name: (D-Phe5,Cys6·11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide
CAS Number: 340821-13-8
Molecular Formula: C₅₀H₆₇N₁₁O₁₀S₂
Molecular Weight: 1046.26000
Catalog: Signaling Pathways GPCR/G Protein Somatostatin Receptor
Create Date: 2017-01-14 06:07:38
Modify Date: 2024-01-20 08:45:34
(D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide (Compound 4) is a somatostatin analog with Kds of 0.61, 11.05, 23.5, 1200 and >1000 nM for SSTR5, SSTR3, SSTR2, SSTR1 and SSTR4, respectively[1].

Name	(D-Phe5,Cys6·11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide
Synonyms	(D-PHE5,CYS6,11,N-ME-D-TRP8)-SOMATOSTATIN-14 (5-12) AMIDE H-D-PHE-CYS-PHE-N-ME-D-TRP-LYS-THR-CYS-THR-NH2 (D-Phe5,Cys6 (N-Me-D-Trp4,Thr8)-Octreotide aMide,(N-Me-D-Trp4)-Octreotate aMide H-D-Phe-Cys-Phe-N-Me-D-Trp-Lys-Thr-Cys-Thr-NH2,(Disulfide bond)

Description	(D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide (Compound 4) is a somatostatin analog with Kds of 0.61, 11.05, 23.5, 1200 and >1000 nM for SSTR5, SSTR3, SSTR2, SSTR1 and SSTR4, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor Research Areas >> Neurological Disease
Target	Kd: 0.61 nM (SSTR5), 11.05 nM (SSTR3), 23.5 nM (SSTR2), 1200 nM (SSTR1), >1000 nM (SSTR4)[1]
References	[1]. Nikiforovich GV, et al. Molecular modeling suggests conformational scaffolds specifically targeting five subtypes of somatostatin receptors. Chem Biol Drug Des. 2007 Mar;69(3):163-9.