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China
Product Name: Epigoitrin
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BioBioPha
China
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ShangHai DC Chemicals Co.,Ltd
China
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DC Chemicals Limited
China
Product Name: Epigoitrin
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1072-93-1

1072-93-1 structure

1072-93-1 structure

Name: Epigoitrin
Chemical Name: goitrine
CAS Number: 1072-93-1
Molecular Formula: C₅H₇NOS
Molecular Weight: 129.180
Catalog: Biochemical Plant extracts
Create Date: 2018-07-10 17:54:40
Modify Date: 2024-01-02 10:53:13
Epigoitrin is a natural alkaloid from Isatis indigotica, with antiviral activities. Epigoitrin reduces susceptibility to influenza virus via mitochondrial antiviral signaling[1][2].

Name	goitrine
Synonyms	5-vinyloxazolidin-2-thione Goitrin Epigoitrin 5-vinyl-2-oxazolidinethione Goitrine Epigoitrin (5R)-5-Vinyl-1,3-oxazolidine-2-thione 2-Oxazolidinethione, 5-ethenyl-, (5R)- (R)-5-Ethenyl-2-oxazolidinethione goitrin, (±)-isomer R-5-vinyl-2-thiooxazolidone 2-Oxazolidinethione, 5-vinyl-, DL- oxazolidine-2-thione, 5-vinyl- R-5-Vinyl-2-oxazolidinethione 5-vinyloxazolidine-2-thione DL-Goitrin RS-Goitrin 5-Vinyl-1,3-oxazolidine-2-thione 2-Oxazolidinethione, 5-ethenyl- R-GOITRIN UNII:O8KVD7J2P5 5-Vinyloxazolidone-2-thione 5-vinyl-2-thiooxazolidone D-Goitrin

Description	Epigoitrin is a natural alkaloid from Isatis indigotica, with antiviral activities. Epigoitrin reduces susceptibility to influenza virus via mitochondrial antiviral signaling[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection
References	[1]. Luo Z, et al. Epigoitrin, an Alkaloid From Isatis indigotica, Reduces H1N1 Infection in Stress-Induced Susceptible Model in vivo and in vitro. Front Pharmacol. 2019 Feb 7;10:78. [2]. Xiao P, et al. Antiviral activities against influenza virus (FM1) of bioactive fractions and representative compounds extracted from Banlangen (Radix Isatidis). J Tradit Chin Med. 2016 Jun;36(3):369-76.

Density	1.2±0.1 g/cm3
Boiling Point	150.6±43.0 °C at 760 mmHg
Melting Point	50ºC
Molecular Formula	C₅H₇NOS
Molecular Weight	129.180
Flash Point	44.9±28.2 °C
Exact Mass	129.024841
PSA	53.35000
LogP	0.38
Appearance	solid
Vapour Pressure	3.8±0.3 mmHg at 25°C
Index of Refraction	1.570

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RQ2280000

CHEMICAL NAME :: 2-Oxazolidinethione, 5-vinyl-, (R)-

CAS REGISTRY NUMBER :: 1072-93-1

LAST UPDATED :: 199403

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C5-H7-N-O-S

MOLECULAR WEIGHT :: 129.19

WISWESSER LINE NOTATION :: T5MYOTJ BUS D1U1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953- Volume(issue)/page/year: 17,483,1969 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 120 mg/kg/4D-I

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in thyroid weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,279,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 200 mg/kg

SEX/DURATION :: female 8-9 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 18,159,1980

Hazard Codes	Xi
Safety Phrases	24/25
HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%