73090-70-7

73090-70-7 structure

Name: EPIROPRIM
Chemical Name: 5-[(3,5-diethoxy-4-pyrrol-1-ylphenyl)methyl]pyrimidine-2,4-diamine
CAS Number: 73090-70-7
Molecular Formula: C₁₉H₂₃N₅O₂
Molecular Weight: 353.41800
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-03-12 08:00:00
Modify Date: 2024-03-04 08:28:18
Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor. Epiroprim displays excellent activity against staphylococci, enterococci, pneumococci, and streptococci[1].

Name	5-[(3,5-diethoxy-4-pyrrol-1-ylphenyl)methyl]pyrimidine-2,4-diamine
Synonyms	Ro 11-8958 2,4-Pyrimidinediamine,5-((3,5-diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl) Epiroprima [INN-Spanish] 5-((3,5-Diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)-2,4-pyrimidinediamine Epiroprimum [INN-Latin] Epiroprime [INN-French] Epiroprim

Description	Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor. Epiroprim displays excellent activity against staphylococci, enterococci, pneumococci, and streptococci[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. H H Locher, et al. Antibacterial activities of epiroprim, a new dihydrofolate reductase inhibitor, alone and in combination with dapsone. Antimicrob Agents Chemother. 1996 Jun;40(6):1376-81.

CHEMICAL NAME :: 2,4-Pyrimidinediamine, 5-((3,5-diethoxy-4-(1H-pyrrol-1-yl)phenyl)methyl)-

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JCHEEU Journal of Chemotherapy. (Edizioni Riviste Scientifiche, via R. Giuliani, 419, 50141 Florence, Italy) V.1- 1989- Volume(issue)/page/year: 5,400,1993