1150-59-0

1150-59-0 structure

Name: 4-hydroxy-3-phenyl-naphthalene-1,2-dione
Chemical Name: 2-hydroxy-3-phenylnaphthalene-1,4-dione
CAS Number: 1150-59-0
Molecular Formula: C₁₆H₁₀O₃
Molecular Weight: 250.24900
Catalog: Research Areas Infection
Create Date: 2016-07-25 21:47:09
Modify Date: 2024-01-02 08:04:38
Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent[1].

Name	2-hydroxy-3-phenylnaphthalene-1,4-dione
Synonyms	2-methyl-2-propenoicaci2-hydroxy-3-phenoxypropylester Methacrylic acid 2-hydroxy-3-phenoxypropyl ester 2-hydroxynaphthoquinone 2-Hydroxy-3-phenoxypropyl-methacrylat 3-PHENOXY-2-HYDROXYPROPYL METHACRYLATE 2-hydroxy-3-phenyl-1,4-naphthalenedione 2-Hydroxy-3-phenyl-[1,4]naphthochinon 3-Phenoxy-2-hydroxypropyl methacryla 2-Propenoicacid,2-methyl-,2-hydroxy-3-phenoxypropylester 3-hydroxy-2-phenyl-1,4-naphthoquinone 2-hydroxy-3-phenyl-1,4-naphthoquinone 3-O-Phenylglycerol 1-methacrylate

Description	Antimalarial agent 14 (Compound N3) is a potent inhibitor of mitochondrial electron transport. Antimalarial agent 14 can serve as an anti-malarial agent[1].
Related Catalog	Research Areas >> Infection
Target	mitochondrial electron transport[1]
In Vitro	Antimalarial agent 14 (Compound N3) (0-400 μM, 48 h) inhibits P. falciparum with limited cytotoxicity against human cells[1]. Antimalarial agent 14 inhibits P. falciparum mitochondrial membrane potential with an IC50ΔΨmit of 16 μM[1]. Cell Cytotoxicity Assay[1] Cell Line: P. falciparum and HEK293T Concentration: 0.128, 0.64, 3.2, 16, 80 and 400 μM Incubation Time: 48 h Result: Showed inhibition with an IC50 of 443 nM against P. falciparum and showed cytotoxicity with a CC50 of 54.6 ± 0.23 μM.
References	[1]. Schuck DC, et al. Biological evaluation of hydroxynaphthoquinones as anti-malarials. Malar J. 2013 Jul 10;12:234.