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146672-58-4

146672-58-4 structure
146672-58-4 structure
  • Name: PAPA NONOate
  • Chemical Name: N-[3-aminopropyl(propyl)amino]-N-hydroxynitrous amide
  • CAS Number: 146672-58-4
  • Molecular Formula: C6H16N4O2
  • Molecular Weight: 176.217
  • Catalog: Research Areas Endocrinology
  • Create Date: 2016-05-15 15:54:50
  • Modify Date: 2024-01-11 18:28:11
  • PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential treatment for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3].

Name N-[3-aminopropyl(propyl)amino]-N-hydroxynitrous amide
Synonyms 3-(2-hydroxy-2-nitroso-1-propylhydrazino)-1-propanamine
1-Propanamine, 3-(2-hydroxy-3-oxo-1-propyltriazanyl)-
1-Hydroxy-2-oxo-3-(3-aminopropyl)-3-propyl-1-triazene
PAPA NONOate
1-Propanamine,3-(2-hydroxy-2-nitroso-1-propylhydrazinyl)
1-(3-Aminopropyl)-2-hydroxy-3-oxo-1-propyltriazane
NOC-15
Description PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential treatment for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3].
Related Catalog
In Vitro PAPA NONOate (50 μM; 12 h) significantly reduces 70% caspase-3-like activity in caspase-3-overexpressing HUVEC and abolishs the induction of cell death by caspase-3[1].
In Vivo PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound[2]. Animal Model: Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound[2] Dosage: 100 μM Administration: Wounds received 100 μM PAPA NONOate in phosphate buffer Result: Increased the wound healing rate in test group.
Density 1.2±0.1 g/cm3
Boiling Point 277.2±42.0 °C at 760 mmHg
Molecular Formula C6H16N4O2
Molecular Weight 176.217
Flash Point 121.4±27.9 °C
Exact Mass 176.127319
PSA 82.16000
LogP 0.20
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.523
Storage condition -20℃
Hazard Codes Xn
Risk Phrases R22