Name | N-[3-aminopropyl(propyl)amino]-N-hydroxynitrous amide |
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Synonyms |
3-(2-hydroxy-2-nitroso-1-propylhydrazino)-1-propanamine
1-Propanamine, 3-(2-hydroxy-3-oxo-1-propyltriazanyl)- 1-Hydroxy-2-oxo-3-(3-aminopropyl)-3-propyl-1-triazene PAPA NONOate 1-Propanamine,3-(2-hydroxy-2-nitroso-1-propylhydrazinyl) 1-(3-Aminopropyl)-2-hydroxy-3-oxo-1-propyltriazane NOC-15 |
Description | PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential treatment for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site[1][2][3]. |
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Related Catalog | |
In Vitro | PAPA NONOate (50 μM; 12 h) significantly reduces 70% caspase-3-like activity in caspase-3-overexpressing HUVEC and abolishs the induction of cell death by caspase-3[1]. |
In Vivo | PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound[2]. Animal Model: Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound[2] Dosage: 100 μM Administration: Wounds received 100 μM PAPA NONOate in phosphate buffer Result: Increased the wound healing rate in test group. |
Density | 1.2±0.1 g/cm3 |
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Boiling Point | 277.2±42.0 °C at 760 mmHg |
Molecular Formula | C6H16N4O2 |
Molecular Weight | 176.217 |
Flash Point | 121.4±27.9 °C |
Exact Mass | 176.127319 |
PSA | 82.16000 |
LogP | 0.20 |
Vapour Pressure | 0.0±1.3 mmHg at 25°C |
Index of Refraction | 1.523 |
Storage condition | -20℃ |