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34320-83-7

34320-83-7 structure
34320-83-7 structure
  • Name: CAY10550
  • Chemical Name: 5-(4-nitrophenyl)-2-phenyl-4H-pyrazol-3-one
  • CAS Number: 34320-83-7
  • Molecular Formula: C15H11N3O3
  • Molecular Weight: 281.27
  • Catalog: Signaling Pathways Apoptosis Apoptosis
  • Create Date: 2016-08-13 17:55:36
  • Modify Date: 2024-01-12 19:14:58
  • TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis[1].
Name 5-(4-nitrophenyl)-2-phenyl-4H-pyrazol-3-one
Synonyms TCS PRP INHIBITOR 13
Necrosulfonamide
1-Phenyl-3-p-nitrophenylpyrazolon
3H-Pyrazol-3-one, 2,4-dihydro-5-(4-nitrophenyl)-2-phenyl-
5-(4-Nitrophenyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
Description TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis[1].
Related Catalog
Target

IC50: 3 nM (PrPC in ScN2a and F3 cells)[1]

In Vitro TCS PrP Inhibitor 13 (0~500 μM; Schwannoma cells) significantly reduces levels of total ERK1/2, pAKT, total FAK, Cyclin D1, PrPC and significantly increases expression of cleaved caspase-3. TCS PrP Inhibitor 13 (Schwannoma cells) significantly reduces the number of proliferating, Ki67-positive cells and total cell number[2].
References

[1]. Kimata A, et al. New series of antiprion compounds: pyrazolone derivatives have the potent activity of inhibiting protease-resistant prion protein accumulation [published correction appears in J Med Chem. 2008 Mar 13;51(5):1503]. J Med Chem. 2007;50(21):5053-5056.

[2]. Provenzano L, et al. Cellular prion protein (PrPC) in the development of Merlin-deficient tumours. Oncogene. 2017;36(44):6132-6142.
Density 1.4±0.1 g/cm3
Boiling Point 445.1±47.0 °C at 760 mmHg
Molecular Formula C15H11N3O3
Molecular Weight 281.27
Flash Point 223.0±29.3 °C
Exact Mass 281.080048
PSA 78.49000
LogP 1.92
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.674
HS Code 2933199090
838-57-3 structure

838-57-3

100-63-0 structure

100-63-0

~82%

34320-83-7 structure

34320-83-7

Literature: Kimata, Ayako; Nakagawa, Hidehiko; Ohyama, Ryo; Fukuuchi, Tomoko; Ohta, Shigeru; Suzuki, Takayoshi; Miyata, Naoki Journal of Medicinal Chemistry, 2007 , vol. 50, # 21 p. 5053 - 5056
89-25-8 structure

89-25-8

61466-08-8 structure

61466-08-8

~0%

61466-03-3 structure

61466-03-3

34320-83-7 structure

34320-83-7

Literature: Azev; Teplyashina Chemistry of Heterocyclic Compounds, 1998 , vol. 34, # 9 p. 1091 - 1092
HS Code 2933199090
Summary 2933199090. other compounds containing an unfused pyrazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Chemsrc provides CAS#:34320-83-7 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 34320-83-7 | Chemsrc address: https://www.chemsrc.com/en/baike/28453.html

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