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512-04-9

512-04-9 structure
512-04-9 structure
  • Name: Diosgenin
  • Chemical Name: diosgenin
  • CAS Number: 512-04-9
  • Molecular Formula: C27H42O3
  • Molecular Weight: 414.621
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-02-04 08:00:00
  • Modify Date: 2024-01-02 11:27:09
  • Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway.
Name diosgenin
Synonyms EINECS 208-134-3
3β-Hydroxy-5-spirostene
Diosgenin
(25R)-5-Spirosten-3β-ol
MFCD00016887
DELTA 5,20A,22A,25D-SPIROSTEN-3BETA-OL
Description Diosgenin, a steroidal saponin, can inhibit STAT3 signaling pathway.
Related Catalog
Target

STAT3

In Vitro In MC65 cells, a cellular AD model, diosgenin exhibited weak protective abilities at 1 μM, may represent a good candidate as a steroidal moiety in our bivalent compounds against AD pathology[1]. Diosgenin inhibits the constitutive activation of STAT3 in C3A cells in a dose-dependent manner, with maximum inhibition occurring at around 100 μM[2].
In Vivo Diosgenin treatment significantly reduces fasted and refed blood glucose level in HF dietfed mice. Diosgenin treatment significantly reduces blood glucose level in IPGTT test, compared with that of HF diet-fed mice[3].
References

[1]. Jeremy E. Chojnacki, et al. Bivalent ligands incorporating curcumin and diosgenin asmultifunctional compounds against Alzheimer’s disease. Bioorganic & Medicinal Chemistry, 23 (2015) 7324–7331

[2]. Li F, et al. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010 Jun 28;292(2):197-207.

[3]. Wang X, et al. Effect of diosgenin on metabolic dysfunction: Role of ERβ in the regulation of PPARγ. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):286-96.
Density 1.1±0.1 g/cm3
Boiling Point 527.1±50.0 °C at 760 mmHg
Melting Point 205-208°C
Molecular Formula C27H42O3
Molecular Weight 414.621
Flash Point 272.6±30.1 °C
Exact Mass 414.313385
PSA 38.69000
LogP 5.84
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.564
Storage condition Refrigerator
Water Solubility chloroform: 20 mg/mL, clear, slightly yellow

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WH1450000
CHEMICAL NAME :
Spirost-5-en-3-beta-ol, (25R)-
CAS REGISTRY NUMBER :
512-04-9
BEILSTEIN REFERENCE NO. :
0094582
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C27-H42-O3
MOLECULAR WEIGHT :
414.69
WISWESSER LINE NOTATION :
T F5 E5 B666 HXO OUTJ A1 E1 G1 RQ H-& BT6OXTJ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1095,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4872 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1095,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1095,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3564 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1095,1977
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 26-36/37
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS WH1450000
HS Code 2932999099
HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Chemsrc provides CAS#:512-04-9 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 512-04-9 | Chemsrc address: https://www.chemsrc.com/en/baike/314541.html

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