73255-40-0

73255-40-0 structure

Name: Moringin
Chemical Name: glucomoringin isothiocyanate
CAS Number: 73255-40-0
Molecular Formula: C₁₄H₁₇NO₅S
Molecular Weight: 311.35300
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2017-08-27 11:41:57
Modify Date: 2024-01-04 18:06:47
Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities[1][2].

Name	glucomoringin isothiocyanate
Synonyms	4-(α-L-rhamnopyranosyloxy)benzyl isothiocyanate 4-(α-L-Rhamnosyloxy)benzyl isothiocyanate 4(α-L-rhamnosyloxy)-benzyl isothiocyanate [4-(α-L-rhamnosyloxy)benzyl]isothiocyanate GMG-ITC (4-[(α-L-rhamnosyloxy)benzyl]isothiocyanate)

Description	Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8. Moringin has hypoglycemic, antimicrobial, anti-inflammatory, anticancer and neuroprotection activities[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cancer Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
In Vitro	在 SH-SY5Y 人神经母细胞瘤细胞中，Moringin（16.4 µM；24-72 小时）以时间和浓度依赖性方式显着降低 SH-SY5Y 细胞生长[2]。 Moringin (1.64-8.2 μM; 24 h) 在 SH-SY5Y 细胞中增加 p53、p21 和 Bax 在蛋白质和转录水平的表达。 Moringin 显著增加 caspase 3/9 的基因表达并增强它们的切割，从而启动内在的细胞凋亡级联反应[2]。 Moringin 抑制 NF-κB 的核转位[2]。
In Vivo	在实验性自身免疫性脑脊髓炎 (EAE) 小鼠中，Moringin (10 mg/kg；腹腔注射；每天 1 次，共 5 周) 预处理可使异常的 Wnt-β-catenin 通路正常化，导致 GSK3β 抑制和 β-catenin 上调，从而调节 T 细胞活化 ( CD4 和 FoxP3)，通过激活 PPARγ 抑制主要的炎症介质 (IL-1β、IL-6 和 COX2)。辣木苷增加 EAE 小鼠体内抗氧化 Nrf2 的表达[3]。
References	[1]. Gigliola Borgonovo, et al. Moringin, A Stable Isothiocyanate from Moringa oleifera, Activates the Somatosensory and Pain Receptor TRPA1 Channel In Vitro. Molecules. 2020 Feb 22;25(4):976. [2]. Santa Cirmi, et al. Moringin from Moringa Oleifera Seeds Inhibits Growth, Arrests Cell-Cycle, and Induces Apoptosis of SH-SY5Y Human Neuroblastoma Cells through the Modulation of NF-κB and Apoptotic Related Factors. Int J Mol Sci. 2019 Apr 19;20(8):1930. [3]. Sabrina Giacoppo, et al. Moringin activates Wnt canonical pathway by inhibiting GSK3β in a mouse model of experimental autoimmune encephalomyelitis. Drug Des Devel Ther. 2016 Oct 4;10:3291-3304.

Molecular Formula	C₁₄H₁₇NO₅S
Molecular Weight	311.35300
Exact Mass	311.08300
PSA	123.60000
LogP	0.49570

Precursor 0
DownStream 1
147821-49-6

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