Name | Stepharine |
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Synonyms | hms1607i01 |
Description | Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor). Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects[1]. |
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Related Catalog | |
In Vitro | Stepharine (10, 30 μM) substantially inhibits nitric oxide (NO) release as well as the mRNA and protein expression of pro-inflammatory mediators [inducible nitric oxide synthase, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β] in LPS-activated BV-2 cells[1]. Stepharine (10, 30 μM) inhibits LPS-induced increase of TLR4 expression, IκBα phosphorylation, and NF-κB p65 nuclear translocation[1]. Stepharine exhibits neuroprotective effects on SH-SY5Y cells cultured with LPS-treated conditioned medium. Stepharine has also shown to inhibit cholinesterase in vitro[1]. |
In Vivo | Stepharine (500 μg/kg) inhibited NeuN+ cells loss and Iba-1+ cells increase in the MCAO ischemic cortex[1]. Animal Model: Middle cerebral artery occlusion (MCAO) rat model[1]. Dosage: 500 μg/kg (20 μL). Administration: Intranasally injected into rats 1h after MCAO. Result: Attenuated the neuronal loss induced by MCAO (MCAO+ stepharine) group. |
References |
Density | 1.27g/cm3 |
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Boiling Point | 487.1ºC at 760 mmHg |
Molecular Formula | C18H19NO3 |
Molecular Weight | 297.34800 |
Flash Point | 248.4ºC |
Exact Mass | 297.13600 |
PSA | 47.56000 |
LogP | 2.55600 |
Vapour Pressure | 1.22E-09mmHg at 25°C |
Index of Refraction | 1.632 |