118248-91-2

118248-91-2 structure

Name: Fodipir
Chemical Name: 2,2'-{1,2-Ethanediylbis[({3-hydroxy-2-methyl-5-[(phosphonooxy)met hyl]-4-pyridinyl}methyl)imino]}diacetic acid (non-preferred name)
CAS Number: 118248-91-2
Molecular Formula: C₂₂H₃₂N₄O₁₄P₂
Molecular Weight: 638.46
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-06-02 08:00:00
Modify Date: 2024-01-03 18:28:38
Fodipir is an active metabolite of mangafodipir, involved in mangafodipir-mediated cytoprotection against 7β-hydroxycholesterol-induced cell death.

Name	2,2'-{1,2-Ethanediylbis[({3-hydroxy-2-methyl-5-[(phosphonooxy)met hyl]-4-pyridinyl}methyl)imino]}diacetic acid (non-preferred name)
Synonyms	N,N'-dipyridoxylethylenediamine-N,N'-diacetic acid-5,5'-bis(phosphate) dihydrate N,N'-di-p-toluoyl-p-benzoquinone diimine Benzamide,N,N'-2,5-cyclohexadiene-1,4-diylidenebis[4-methyl Fodipir

Description	Fodipir is an active metabolite of mangafodipir, involved in mangafodipir-mediated cytoprotection against 7β-hydroxycholesterol-induced cell death.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	Fodipir is an active metabolite of mangafodipir, involved in mangafodipir-mediated cytoprotection against 7β-hydroxycholesterol-induced cell death. Fodipir (Dp-dp; Dipyridoxyl diphosphate; 100 μM) shows the best cytopretective effect on 7β-OH-mediated cell death after treatment for 8 h. Fodipir also reduces 7β-OH-induced cellular ROS production and lysosomal membrane permeabilization (LMP)[1].
References	[1]. Laskar A, et al. Fodipir and its dephosphorylated derivative dipyridoxyl ethyldiamine are involved in mangafodipir-mediated cytoprotection against 7β-hydroxycholesterol-induced cell death. Pharmacology. 2013;92(3-4):182-6.