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  • DC Chemicals Limited
  • China
  • Product Name: IMS2186
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao


1031206-36-6

1031206-36-6 structure
1031206-36-6 structure
  • Name: IMS2186
  • Chemical Name: (3E)-3-(3-Hydroxy-4-methoxybenzylidene)-6-methyl-2,3-dihydro-4H-c hromen-4-one
  • CAS Number: 1031206-36-6
  • Molecular Formula: C18H16O4
  • Molecular Weight: 296.31700
  • Catalog: Research Areas Others
  • Create Date: 2016-06-10 05:37:34
  • Modify Date: 2024-01-14 17:17:59
  • IMS2186 is an antichoroidal neovascularization (CNV) reagent. IMS2186 can arrest cancer cell cycle in G2/M phase, thus exerting anti-proliferation and anti-angiogenesis effects. IMS2186 has no intraocular toxicity and reduces the amount of eye leakage and diseased cells[1].

Name (3E)-3-(3-Hydroxy-4-methoxybenzylidene)-6-methyl-2,3-dihydro-4H-c hromen-4-one
Synonyms Azetidine,3-[1-(3,5-difluorophenyl)-2,2-dimethylpropylidene]
3-[1-(3-hydroxy-4-methoxyphenyl)meth-(E)-ylidene]-6-methylchroman-4-one
3-[1-(3-difluoromethoxy-benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-yl]-azetidine-1-carboxylic acid tert-butyl ester
Description IMS2186 is an antichoroidal neovascularization (CNV) reagent. IMS2186 can arrest cancer cell cycle in G2/M phase, thus exerting anti-proliferation and anti-angiogenesis effects. IMS2186 has no intraocular toxicity and reduces the amount of eye leakage and diseased cells[1].
Related Catalog
In Vitro IMS2186 (0.3-10 μM; 22 h) 抑制剂人成纤维细胞、人癌症细胞增殖,IC50 分别为 1.0-3.0 μM,0.3-3.0 μM[1]。 IMS2186 (0-10 μM; 22 h) 在 10 ng/mL VEGF 刺激下,抑制内皮管形成,IC50 为 0.1-0.3 μM[1]。 IMS2186 (0.1-10 μM; 24 h) 抑制巨噬细胞中促炎细胞因子 PGE2/TNF-a 的产生,IC50 为 0.3-1 μM[1]。 IMS2186 (0.1-10 μM; 1.5 h) 还抑制巨噬细胞迁移,IC50 为 1 μM[1]。 Cell Cycle Analysis[1] Cell Line: Cancer H460 cells Concentration: 3 μM, 10 μM Incubation Time: Result: Showed anti-proliferative activity mediated by arresting cell cycle at G2/M.
In Vivo IMS2186 (2.5 mg in 0.5 mL; 玻璃体注射; 单次剂量) 施用于兔子眼睛后,未出现眼毒性[1]。 IMS2186 (100 μg/眼,即 50 μg/μL 溶液用量 2.0 μL; 单次剂量) 对激光诱导脉络膜新生血管 (CNV) 的大鼠模型表现出抗增殖效力[1]。 Animal Model: Rat model of laser induced CNV[1] Dosage: 100 μg/eye, 2.0 μL of the solution of 50 μg/μL Administration: Intravitreal injection; single dose Result: Resulted 30% reduction of lesion area compared to PBS in the lesion area measurement.
References

[1]. Falkenstein IA, et al. Toxicity and intraocular properties of a novel long-acting anti-proliferative and anti-angiogenic compound IMS2186. Curr Eye Res. 2008 Jul;33(7):599-609.  

Molecular Formula C18H16O4
Molecular Weight 296.31700
Exact Mass 296.10500
PSA 55.76000
LogP 3.36790
Symbol GHS09
GHS09
Signal Word Warning
Hazard Statements H400
Precautionary Statements P273
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
RIDADR UN 3077 9 / PGIII