Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Karacoline
Price:
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang

BioBioPha
China
Product Name: Karacoline
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Karacoline
Price: ￥2238.0/20mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: KARAKOLINE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang

39089-30-0

39089-30-0 structure

39089-30-0 structure

Name: Karacoline
Chemical Name: karakoline
CAS Number: 39089-30-0
Molecular Formula: C₂₂H₃₅NO₄
Molecular Weight: 377.518
Catalog: Research Areas Others
Create Date: 2018-03-29 08:00:00
Modify Date: 2024-01-08 06:14:00
Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway[1].

Name	karakoline
Synonyms	(1α,14α,16β)-20-Ethyl-16-methoxy-4-methylaconitane-1,8,14-triol Karacoline Karakoline 20-Ethyl-16-β-methoxy-4-methylaconitane-1-α,8,14-α-triol Aconitane-1,8,14-triol, 20-ethyl-16-methoxy-4-methyl-, (1α,14α,16β)-

Description	Karacoline, a diterpene alkaloid found in the plant Aconitum kusnezoffii, reduces degradation of the extracellular matrix (ECM) in intervertebral disc degeneration (IDD) via the NF-κB signaling pathway[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. XiaoliZhou, et al. Karacoline, identified by network pharmacology, reduces degradation of the extracellular matrix in intervertebral disc degeneration via the NF-κB signaling pathway. Journal of Pharmaceutical Analysis, 2019.

Density	1.3±0.1 g/cm3
Boiling Point	540.2±50.0 °C at 760 mmHg
Molecular Formula	C₂₂H₃₅NO₄
Molecular Weight	377.518
Flash Point	280.5±30.1 °C
Exact Mass	377.256622
PSA	73.16000
LogP	-0.26
Vapour Pressure	0.0±3.3 mmHg at 25°C
Index of Refraction	1.623

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR5569480

CHEMICAL NAME :: Aconitane-1,8,14-triol, 20-ethyl-16-methoxy-4-methyl-, (1-alpha,14-alpha,16-beta)-

CAS REGISTRY NUMBER :: 39089-30-0

LAST UPDATED :: 199412

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C22-H35-N-O4

MOLECULAR WEIGHT :: 377.58

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 298 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 51500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

RTECS	AR5569480