Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (R)-(-)-NIGULDIPINE HYDROCHLORIDE
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Purity: 98.0%
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189624-85-9

189624-85-9 structure

189624-85-9 structure

Name: (R)-(-)-NIGULDIPINE HYDROCHLORIDE
Chemical Name: 5-O-ethenyl 3-O-methyl (2S)-2-[4-(4-benzhydrylpiperazin-1-yl)phenyl]-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydro-1H-pyridine-3,5-dicarboxylate,dihydrochloride
CAS Number: 189624-85-9
Molecular Formula: C₄₁H₄₄Cl₂N₄O₆
Molecular Weight: 759.71700
Create Date: 2016-04-19 22:33:00
Modify Date: 2024-01-24 05:13:51

Name	5-O-ethenyl 3-O-methyl (2S)-2-[4-(4-benzhydrylpiperazin-1-yl)phenyl]-2,6-dimethyl-4-(3-nitrophenyl)-3,4-dihydro-1H-pyridine-3,5-dicarboxylate,dihydrochloride
Synonyms	(S)-(+)-Watanidipine hydrochloride BY 935 Watanidipine hydrochloride (S)-enantiomer (S)-AE0047 (R)-Nigaldipine hydrochloride 3,5-Pyridinedicarboxylic acid,1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-,2-(4-(4-(diphenylmethyl)-1-piperazinyl)phenyl)ethyl methyl ester,dihydrochloride,(S)-(+) (-)-Nigaldipine hydrochloride B 8509-035

Boiling Point	780.5ºC at 760 mmHg
Molecular Formula	C₄₁H₄₄Cl₂N₄O₆
Molecular Weight	759.71700
Flash Point	425.8ºC
Exact Mass	758.26400
PSA	116.93000
LogP	9.31740
Vapour Pressure	2.62E-24mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: US7201200

CHEMICAL NAME :: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-(4-(4- (diphenylmethyl)-1-piperazinyl)phenyl)ethyl methyl ester, dihydrochloride, (S)-(+)-

CAS REGISTRY NUMBER :: 189624-85-9

LAST UPDATED :: 199806

DATA ITEMS CITED :: 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: >12 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - conjunctive irritation Behavioral - somnolence (general depressed activity) Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 25(Suppl 3),S745,1997 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 14850 ug/kg/9D-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), diffuse Blood - normocytic anemia Related to Chronic Data - death

REFERENCE :: YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972- Volume(issue)/page/year: 25(Suppl 3),S793,1997