87530-30-1

87530-30-1 structure

Name: Lusianthridin
Chemical Name: 7-methoxy-9,10-dihydrophenanthrene-2,5-diol
CAS Number: 87530-30-1
Molecular Formula: C₁₅H₁₄O₃
Molecular Weight: 242.27000
Catalog: Signaling Pathways Apoptosis c-Myc
Create Date: 2017-07-16 20:36:00
Modify Date: 2024-01-12 16:54:20
Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling[1].

Name	7-methoxy-9,10-dihydrophenanthrene-2,5-diol
Synonyms	Lusianthridin

Description	Lusianthridin, a pure compound from Dendrobium venustum, have an anti-migratory effect. Lusianthridin enhances c-Myc degradation through the inhibition of Src-STAT3 signaling[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Apoptosis >> c-Myc
In Vitro	Lusianthridin (0-100 μM) inhibits cell viability at concentrations greater than 50 μM in both H460 and H292 cells[1]. Lusianthridin significantly reduces the CSC populations in both H460 and H292 cells of the CSC spheres, with a significant decrease in the size of the H460 CSC spheres by approximately 10%, 63%, and 77% at day 3 at concentration 5, 10, and 20 μM Lusianthridin, respectively[1]. Cell Viability Assay[1] Cell Line: The human non-small cell lung cancer cell lines, NCI-H460, and NCI-H292 cells[1].0-100 μM. Concentration: 0-100 μM. Incubation Time: 24 h. Result: Caused a significant reduction in terms of cell viability at concentrations greater than 50 μM in both H460 and H292 cells.
References	[1]. Narumol Bhummaphan, et al. Targeting of Lung Cancer Stem Cells via Src-STAT3 Suppression. Phytomedicine. 2019 Sep;62:152932.