251111-30-5

251111-30-5 structure

Name: Beloranib
Chemical Name: [(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]prop-2-enoate
CAS Number: 251111-30-5
Molecular Formula: C₂₉H₄₁NO₆
Molecular Weight: 499.63900
Create Date: 2016-12-23 13:05:25
Modify Date: 2024-01-02 13:36:36
Beloranib is an antiangiogenic fumagillin derivative. Beloranib decreases food intake, body weight, fat mass, and the size of adipocytes.

Name	[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] (E)-3-[4-[2-(dimethylamino)ethoxy]phenyl]prop-2-enoate
Synonyms	[(3R,6R,7S,8S)-7-methoxy-8-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-2-oxaspiro[2.5]octan-6-yl] (E)-3-[4-(2-dimethylaminoethyloxy)phenyl]prop-2-enoate (3R,4S,5S,6R)-5-Methoxy-4-((2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl)-1-oxaspiro(2.5)octan-6-yl (2E)-3-(4-(2-(dimethylamino)ethoxy)phenyl)prop-2-enoate Beloranib UNII-FI471K8BU6 O-(4-(2-Dimethylaminoethoxy)-trans-cinnamoyl)fumagillol Beloranib [INN] ZGN-433

Description	Beloranib is an antiangiogenic fumagillin derivative. Beloranib decreases food intake, body weight, fat mass, and the size of adipocytes.
References	[1]. Elfers CT, Roth CL. Robust Reductions of Excess Weight and Hyperphagia by Beloranib in Rat Models of Genetic and Hypothalamic Obesity. Endocrinology. 2017;158(1):41-55. [2]. Kim YM, An JJ, Jin YJ, et al. Assessment of the anti-obesity effects of the TNP-470 analog, CKD-732. J Mol Endocrinol. 2007;38(4):455-465. [3]. Lee HS, Choi WK, Son HJ, et al. Absorption, distribution, metabolism, and excretion of CKD-732, a novel antiangiogenic fumagillin derivative, in rats, mice, and dogs. Arch Pharm Res. 2004;27(2):265-272. [4]. Kim EJ, Shin WH. General pharmacology of CKD-732, a new anticancer agent: effects on central nervous, cardiovascular, and respiratory system. Biol Pharm Bull. 2005;28(2):217-223.