Name | troleandomycin |
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Synonyms |
tao
TRIACETYLOLEANDOMYCIN TROLEANDOMYCIN Taocin evramicina cyclamycin Tri-O-acetyl-oleandomycin EINECS 220-392-9 Mathromycin T OLEANDOMYCIN TRIACETATE |
Description | Troleandomycin (Triacetyloleandomycin), a macrolide acrolide antibiotic, is a selective CYP3A inhibitor. Troleandomycin is an oral corticosteroid for asthma study[1][2][3]. |
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Related Catalog | |
In Vitro | Troleandomycin markedly inhibits 6β-hydroxylation of testosterone, 25- and 26-hydroxylations of 5β-cholestane-3α,7α,12α-triol and 23R-, 24R-, 24S-, and 27-hydroxylations of 5β-cholestane-3α,7α,12α,25-tetrol in both recombinant CYP3A4 and microsomes, but IC50 values for microsomes are somewhat higher than those for recombinant CYP3A4[1]. |
In Vivo | Troleandomycin markedly suppresses these microsomal side chain hydroxylations in both mouse and human livers in a dose-dependent manner[2]. Animal Model: SD female rats[1]. Dosage: 500 mg/kg. Administration: A single oral dose. Result: Markedly elevated the Cmax and AUC0-6 of simvastatin by 9.5- and 10.2-fold, respectively. |
References |
Density | 1.19g/cm3 |
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Boiling Point | 812.5ºC at 760mmHg |
Melting Point | 170 °C (lit.) |
Molecular Formula | C41H67NO15 |
Molecular Weight | 813.96800 |
Flash Point | 445.2ºC |
Exact Mass | 813.45100 |
PSA | 184.19000 |
LogP | 3.62090 |
Vapour Pressure | 1.82E-26mmHg at 25°C |
Index of Refraction | 1.515 |
Storage condition | -20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Hazard Codes | Xi |
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Risk Phrases | 36/37/38 |
Safety Phrases | S22-S24/25 |
WGK Germany | 2 |
RTECS | RJ9900000 |
~% 2751-09-9 |
Literature: GB877730 , ; Antibiotics Annual, p. 476,479 |
Precursor 1 | |
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DownStream 0 |