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3466-75-9

3466-75-9 structure
3466-75-9 structure
  • Name: Dihydrotetrabenazine
  • Chemical Name: 9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol
  • CAS Number: 3466-75-9
  • Molecular Formula: C19H29NO3
  • Molecular Weight: 319.439
  • Create Date: 2016-07-20 13:54:39
  • Modify Date: 2024-01-11 09:09:09
  • Dihydrotetrabenazine (racemic) is an active metabolite of the vesicular monoamine transporter 2 (VMAT2) inhibitor tetrabenazine that is generated by hepatic carbonyl reductases. Dihydrotetrabenazine binds to mouse pons medulla, hypothalamus, and striatum and inhibits synaptic vesicular serotonin (5-HT) uptake. It also binds to human caudate nucleus, hippocampus, and substantia nigra pars compacta. Dihydrotetrabenazine stereoisomers bind to VMAT2 in rat striatum.

Name 9,10-dimethoxy-3-(2-methylpropyl)-2,3,4,6,7,11b-hexahydro-1H-benzo[a]quinolizin-2-ol
Synonyms 2-Hydroxy-3-isobutyl-9,10-dimethoxy-1,2,3,4,6,7-hexahydro-11bH-benzo(a)quinolizine
2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-
3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ol
2H-Benzo(a)quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-
3-isobutyl-9-methoxy-10-methoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2-ol
2-Hydroxytetrabenazine
trans (2,3)-Dihydro Tetrabenazine
Density 1.1±0.1 g/cm3
Boiling Point 457.8±45.0 °C at 760 mmHg
Molecular Formula C19H29NO3
Molecular Weight 319.439
Flash Point 230.7±28.7 °C
Exact Mass 319.214752
PSA 41.93000
LogP 3.17
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.562
HS Code 2933990090
Precursor  0

DownStream  1

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%